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Title: Iron deficiency in Yemeni patients with sickle-cell disease
Authors: Kassim, A.
Thabet, S.
Al Kabban, M.
Al Nihari, K.
Issue Date: 2012
Language: English
Abstract: Despite the general view that patients with sickle-cell disease [SCO] have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria [low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age]. Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 [13.3%] met the criteria for iron deficiency, 9 of whom were from the non-transfused patients [20.5%]. The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency
Description: 241-245
Keywords: Anemia, Sickle Cell
Reticulocyte Count
Subject: Iron
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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