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Title: Cross-reaction of antigen preparations from adult and larval stages of the parasite Setaria equina with sera from infected humans with Wuchereria bancrofti
Authors: Bahgat, M.M.
Saad, A.H.
El Shahawi, G.A.
Gad, A.M.
Ramzy, K.M.
Ruppel, A.
Abdel Latif, M.
Issue Date: 2011
Language: English
Abstract: Crude antigenic preparations from Setaria equina were used in ELISA and Western blotting to examine cross-reaction with human sera from areas endemic for bancroftian filariasis. Sera from normal subjects from non-endemic areas were included as negative controls. Cross-reaction was found between 5. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. crude female worm surface antigen [CFSWA]. In the absence of active transmission of Setaria spp. infection, CFWSA is useful to detect chronic W. bancrofti infection before patients become symptomatic, particularly when chronic patients are known to be amicrofilaraemic. In the presence of active 5. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera
Description: 679-686
Keywords: Wuchereria bancrofti
Elephantiasis, Filarial
Enzyme-Linked Immunosorbent Assay
Blotting, Western
Subject: Setaria Nematode
URI: http://www.who.int/iris/handle/10665/118283
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/V17/08/17_8_2011_0679_0686.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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