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Title: Total homocysteine levels and cardiovascular risk factors in healthy Tunisians
Authors: El Oudi, M.
Aouni, Z.
Mazigh, C.
Machghoul, S.
Issue Date: 2011
Language: English
Abstract: Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. This study determined the distribution of homocysteine [Hcy] levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. Randomly selected subjects [592 men and 114 women] were recruited from different regions of Tunisia. The overall mean Hcy level was 12.6 [SD 5.4] micromol/L. Hcy levels in subjects with hyperhomocysteinaemia varied according to geographical region. Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B[12] levels compared with subjects with normohomocysteinaemia. Hey levels correlated with total cholesterol [r= 0.09], apolipoprotein A [r = 0.012], and B [r= 0.013] levels and total/HDL cholesterol ratio [r- =0.085]. Further epidemiological studies are needed to determine the precise role of Hcy in cardiovascular disease
Description: 937-942
Keywords: Cardiovascular Diseases
Risk Factors
Subject: Homocysteine
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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