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Title: Interferon-gamma release assay for detection of latent tuberculosis infection in casual and close contacts of tuberculosis cases
Authors: Abu Taleb, A.M.F.
El Sokkary, R.H.
El Tarhouny, S.A.
Issue Date: 2011
Language: English
Abstract: The tuberculin skin test [TST] has many limitations for the diagnosis of latent tuberculosis [TB] infection. The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay [IFN-gamma] assay for the detection of latent TB infection in contacts of active TB cases. A total of 116 participants were enrolled and divided into 3 groups: community controls, casual [laboratory and clinic] contacts and close [household] contacts. Subjects diagnosed with latent TB infection by TST were 11.5% of controls, 71.1% of casual contacts and 29.6% of close contacts. Subjects diagnosed as latent TB infection by IFN-gamma assay [QuantiFERON-TB Gold In-Tube] were 5.9% of controls, 31.0% of casual contacts and 33.3% of close contacts. The overall agreement between TST and IFN-gamma was 66.7% [K= 0.28]. The IFN-gamma method could be more helpful than TST for detection of latent TB infection in contacts
Description: 749-753
Keywords: Latent Tuberculosis
Tuberculin Test
Cross-Sectional Studies
Subject: Latent Tuberculosis
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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