Interferon-gamma release assay for detection of latent tuberculosis infection in casual and close contacts of tuberculosis cases
AbstractThe tuberculin skin test [TST] has many limitations for the diagnosis of latent tuberculosis [TB] infection. The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay [IFN-gamma] assay for the detection of latent TB infection in contacts of active TB cases. A total of 116 participants were enrolled and divided into 3 groups: community controls, casual [laboratory and clinic] contacts and close [household] contacts. Subjects diagnosed with latent TB infection by TST were 11.5% of controls, 71.1% of casual contacts and 29.6% of close contacts. Subjects diagnosed as latent TB infection by IFN-gamma assay [QuantiFERON-TB Gold In-Tube] were 5.9% of controls, 31.0% of casual contacts and 33.3% of close contacts. The overall agreement between TST and IFN-gamma was 66.7% [K= 0.28]. The IFN-gamma method could be more helpful than TST for detection of latent TB infection in contacts
Abu Taleb, A.M.F., El Sokkary, R.H. & El Tarhouny, S.A. (2011). Interferon-gamma release assay for detection of latent tuberculosis infection in casual and close contacts of tuberculosis cases. http://www.who.int/iris/handle/10665/118210
EMHJ - Eastern Mediterranean Health Journal, 17 (10), 749-753, 2011
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