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Title: Evaluation of two doses of triclabendazole in treatment of patients with combined schistosomiasis and fascioliasis
Authors: Osman, M.M.
Shehab, A.Y.
Zaki, A.
Farag, H.F.
Issue Date: 2011
Language: English
Abstract: To determine the safety and efficacy of 2 consecutive doses of triclabendazole [TCBZ] in the treatment of Schistosoma mansoni infection in human cases infected with both S. mansoni and Fasdola spv we conducted afield survey involving 6314 individuals from 15 villages. The overall prevalence of schistosomiasis alone was 15.8%, of fascioliasis alone 2.2%, and of combined infection 0.7%. Treatment with 2 doses of TCBZ was given to the 49 cases with combined infection. Eight weeks after treatment, the cure rate was 96% for fascioliasis and was 32.7% for schistosorniasis. All schistosomiasis cases cured had a low intensity infection. Liver function tests done before I treatment and 8 weeks after substantiate the safety of 2 doses of TCBZ given to those with combined infection. Administration of TCBZ should precede praziquantel in treatment of combined infection, however TCBZ cannot be recommended for infection with S. mansoni alone
Description: 266-270
Keywords: Fascioliasis
Benzimidazoles
Benzimidazoles
Treatment Outcome
Evaluation Studies as Topic
Subject: Schistosomiasis
URI: http://www.who.int/iris/handle/10665/118114
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/V17/04/17_4_2011_0266_0270.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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