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Title: Seroresponse to the second measles vaccine dose at school entry in Qassim province, Saudi Arabia
Authors: Khalil, M.K.M.
Nadrah, H.M.
Al Yahla, O.A.
El Ghazali, G.
Issue Date: 2011
Language: English
Abstract: In 2001, the measles immunization schedule in Saudi Arabia was changed to 2 measles, mumps and rubella vaccine doses at 12 months and at 6 years. In this follow-up study we evaluated the seroresponse to the second measles dose before school entry. We recruited 138 children randomly from primary health care centres in Qassinn; 124 children completed the study. Blood samples were collected before and 1 month after giving the second measles dose, before the age of 6 years. There was a statistically significant increase in the geometric mean titre of measles antibody, from 2205 m lU/mL before vaccination to 4723 mlU/mL after [P = 0.0001]. The proportion of children with positive ELISA results increased fro++ 94.2% before vaccination to 99.2% after [P = 0.02], while the proportion with protective level [^200 mlU/mL] increased from 97.1% before vaccination to 99.19% after [P= 0.21]. The 2-dose measles immunization schedule can produce optimum protection at school entry if high vaccination coverage is guaranteed
Description: 191-195
Keywords: Immunization, Secondary
Immunization Schedule
Enzyme-Linked Immunosorbent Assay
Subject: Measles Vaccine
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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