Eosinophilic cationic protein: is it useful in assessing control of childhood asthma?
AbstractThis study evaluated peripheral eosinophil and serum eosinophilic cationic protein [s-ECP] levels as markers of asthma control. A total of 38 children with asthma [16 controlled and 22 partially controlled] were compared with 16 age- and sex-matched healthy children. Total asthma cases had higher eosinophil counts and s-ECP levels than healthy children and partially controlled asthmatics had significantly higher levels of both markers than controlled asthmatics. Controlled asthma cases showed non-significant changes in both parameters versus healthy children. A negative correlation was noted between degree of asthma control and both eosinophil counts and s-ECP levels [r = -0.60 and -0.75 respectively]. s-ECP as well as peripheral eosinophil count may be helpful in the assessment of asthma control
Zedan, M., Settin, A., El Chennawi, F., El Desouky, T., Nasef, N. et al. (2010). Eosinophilic cationic protein: is it useful in assessing control of childhood asthma?. http://www.who.int/iris/handle/10665/118001
EMHJ - Eastern Mediterranean Health Journal, 16 (10), 1045-1049, 2010
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Eosinophil cationic protein as a serological marker of disease activity in childhood bronchial asthma Badr El Din, O.M. (1999)To study the value of eosinophil cationic protein [ECP] as a serological marker of disease activity in childhood bronchial asthma, ECP levels were measured in 20 healthy control children and 25 asthmatic children, during and 2 weeks after acute exacerbation. The mean serum ECP level of all asthmatic patients, during and after exacerbation, was significantly higher than the control group and was significantly higher during attacks than 2 weeks after their termination. ECP levels were highest in severe attacks, but did not differ between mild and ...