Comparison of erythrocyte indices to differentiate between iron deficiency and alpha-thalassaemias in children with microcytosis and/or hypochromia
AbstractErythrocyte indices used to differentiate between iron deficiency anaemia [IDA] and thalassaemias have been studied mainly in countries with a high prevalence of IDA or beta-thalassaemias. This study was carried out in the United Arab Emirates where alpha-thalassaemias are prevalent. We studied the predictive value and Youden index of several indices in 85 children aged 6 months to 12 years with microcytosis and/or hypochromia, with or without anaemia [determined by serum measurement of iron or therapeutic iron trial]. The best discriminatory indices for detecting IDA versus alpha-thalassaemias were a Green -King index > 65 [correctly identified 75.3% of children, Youden index 44.3] and red cell distribution width > 14% [correctly identified 57.8%, Youden index 38.1]
Narchi, H. & Basak, R.B. (2010). Comparison of erythrocyte indices to differentiate between iron deficiency and alpha-thalassaemias in children with microcytosis and/or hypochromia. http://www.who.int/iris/handle/10665/117988
EMHJ - Eastern Mediterranean Health Journal, 16 (9), 966-971, 2010
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