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Title: Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal oncology-haematology centre, Qatar
Authors: Ibrahim, F.A.
Yassin, M.A.
El Ayoubi, H.R.
Alhijji, I.A.
Albinali, A.S.
Almansour, S.M.
Qafoud, F.M.
Issue Date: 2010
Language: English
Abstract: This cases series describes the profile of adult patients with acute promyelocytic leukaemia [APL] at a referral hospital in Qatar of 34 acute myeloid leukaemia [AML] cases diagnosed, 11 [32%] were classified as APL. Disseminated intravascular coagulation was common at presentation [91%]. Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant [6 patients], hyperbasophilic [2 patients] and regular nuclear outline M3r [1 patient]. Translocation t[15;17] was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a predominance of APL variants with unfavourable presenting features
Description: 958-965
Keywords: Leukemia, Promyelocytic, Acute
Leukemia, Promyelocytic, Acute
Subject: Leukemia, Promyelocytic, Acute
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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