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Title: Prevalence of factor V Leiden mutation in patients with thrombosis in Tunisia
Authors: Ajem, A.
Slama, A.
Slama, F.B.H.
Mehjoub, T.
Issue Date: 2009
Language: English
Abstract: This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients [102 with venous thrombosis and 26 with arterial thrombosis] attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients [20.3%] than controls [6.0%]. The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified
Description: 1483-1488
Keywords: Mutation
Polymerase Chain Reaction
Subject: Factor V
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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