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Title: Defective monocyte phagocytic function as a possible genetic marker for heumatic susceptibility
Authors: Badr El Din, Mostafa K.
Issue Date: 1998
Language: English
Abstract: The activity of the monocyte phagocytic system in children with rheumatic heart disease [RHD], their parents, their normal siblings and in nonrheumatic families was investigated. Phagocytic activity of isolated monocytes was assessed using luminol-dependent chemiluminescence. The count per minute of emitted light was measured before and after stimulation with zymosan solution. The results indicate that one-third of the siblings of children with RHD were genetically free while two-thirds, as well as the parents, were heterozygous, and that children with RHD were homozygous for [a] mutant gene[s] responsible for the defective function of the monocyte phagocytic system. The findings are strongly suggestive of autosomal recessive inheritance
Description: 36-43
Keywords: Rheumatic Fever
Monocytes
Phagocytes
Genetic Markers
Subject: Rheumatic Fever
URI: http://www.who.int/iris/handle/10665/117728
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0401/emhj_1998_4_1_36_43.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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