T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy
AbstractThis study assessed changes in serum levels of cytokines IFNgamma and IL-10 [biomarkers of inflammatory changes] and soluble biomarkers sICAM-1 and sE-selectin [biomarkers of endothelial dysfunction] in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy [DN] and end-stage renal disease [ESRD] compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis
Kamel, L., Morsy, A. & El Shamaa, A. (2009). T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy. http://www.who.int/iris/handle/10665/117702
EMHJ - Eastern Mediterranean Health Journal, 15 (4), 807-816, 2009
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