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Title: T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy
Authors: Kamel, L.
Morsy, A.
El Shamaa, A.
Issue Date: 2009
Language: English
Abstract: This study assessed changes in serum levels of cytokines IFNgamma and IL-10 [biomarkers of inflammatory changes] and soluble biomarkers sICAM-1 and sE-selectin [biomarkers of endothelial dysfunction] in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy [DN] and end-stage renal disease [ESRD] compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis
Description: 807-816
Keywords: Diabetes Mellitus, Type 2
E-Selectin
Interferon-gamma
Interleukin-10
T-Lymphocytes
Endothelium
Creatinine
Renal Dialysis
Subject: Diabetic Nephropathies
URI: http://www.who.int/iris/handle/10665/117702
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1504/15_4_2009_0807_0816.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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