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Title: Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major
Authors: Saffar, M.J.
Saffar, H.
Khalilian, A.R.
Naqshvar, F.
Issue Date: 2009
Language: English
Abstract: Treatment of chronic hepatitis C virus [HCV] infection in transfusion-dependent betathalassaemia major patients is complicated by existing hepatic siderosis and the fear of ribavirinassociated haemolysis. We evaluated the efficacy and side-effects of combination interferon-alpha [INF] and ribavirin therapy for HCV-infected thalassaemia patients. A total of 17 patients were enrolled [10 nonresponders to INF monotherapy, 7 naive to treatment, mean age 23.1 years] and they received 12 months of combination therapy. The sustained virological response rate 6 months after treatment was 58.8%. Blood transfusion requirements during treatment temporarily increased by 36.6%. Combination therapy was tolerated by, and may be useful for, HCV-infected thalassaemia major patients
Description: 785-791
Keywords: Drug Therapy, Combination
Interferons
Ribavirin
beta-Thalassemia
Blood Transfusion
Treatment Outcome
Subject: Hepatitis C, Chronic
URI: http://www.who.int/iris/handle/10665/117699
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1504/15_4_2009_0785_0791.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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