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Title: C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?
Authors: Al Zwaini, E.J.
Issue Date: 2009
Language: English
Abstract: The study aimed to determine whether serum C-reactive protein [CRP] levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. Neonates with suspected neonatal septicaemia treated at a hospital in Al Ramadi city, Iraq, in 2005 had serum CRP and blood cultures [the gold standard] done at admission and at 48 hours, 4 days and 6 days after starting treatment. Of the 55 neonates, CRP was </= 6 mg/L at 48 hours in 37 [67.3%] and antibiotics could be stopped in 32 [82.5%], i.e. when blood culture was negative. The moderate sensitivity [78%] and negative predictive value [86%] of serum CRP in this study suggest that this test alone cannot be used for guiding duration of antibiotic treatment for neonatal sepsis
Description: 269-275
Keywords: Sepsis
Anti-Bacterial Agents
Predictive Value of Tests
Prospective Studies
Intensive Care Units, Neonatal
Subject: C-Reactive Protein
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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