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Title: Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]
Authors: Al Krawi, E.A.A.
Al Hashimi, A.H.M.
Issue Date: 2009
Language: English
Abstract: The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear [PMN] cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole [4.98-24.86 microg/mL] significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN
Description: 224-229
Keywords: Granulocytes
Radiation-Sensitizing Agents
Reactive Oxygen Species
Nitrablue Tetrazolium
Subject: Metronidazole
URI: http://www.who.int/iris/handle/10665/117630
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1501/15_1_2009_0224_0229.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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