|Title:||Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]|
|Authors:||Al Krawi, E.A.A.|
Al Hashimi, A.H.M.
|Abstract:||The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear [PMN] cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole [4.98-24.86 microg/mL] significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN|
Reactive Oxygen Species
|Appears in Collections:||EMRO Journal Articles (EMHJ)|
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