Distinguishing between primary infection and reinfection with rubella vaccine virus by IgG avidity assay in pregnant women
AbstractDuring the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity antirubella IgG and were regarded as cases of reinfection
Hamkar, R., Jalilvand, S., Abdol Baghi, M.H., Jelyani, K.N., Esteghamati, A. et al. (2009). Distinguishing between primary infection and reinfection with rubella vaccine virus by IgG avidity assay in pregnant women. http://www.who.int/iris/handle/10665/117612
EMHJ - Eastern Mediterranean Health Journal, 15 (1), 94-103, 2009
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