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Title: Development of the International Consortium for Blood Safety [ICBS] HCV panels
Authors: Diaz, S.
Liu, P.
Kuhnert, W.L.
Healy, M.
Prince, A.M.
El Nageh, M.M.
Issue Date: 2008
Language: English
Abstract: To evaluate the sensitivity and specificity of assays used to screen blood for antibody to hepatitis C virus [HCV] infection, the International Consortium for Blood Safety [ICBS] established fully characterized ICBS panels. ICBS collected and characterized 1007 anti-HCV-positive plasma units from geographically diverse origins by ELISA, RIBA, RT-PCR, and sequence-based genotyping, 539 of which met the definition of a true positive. Of these, 200 confirmed positive plasma units, representing the 6 major HCV genotypes, were selected to assemble the true-positive constituents of the panel. The negative panel comprises 181 plasma units collected from the USA. The panels have proved valuable for determining the performance of anti-HCV assays thus permitting national authorities, especially in resource-limited countries, to make informed decisions on selection of affordable and reliable assays
Description: 427-437
Keywords: Safety Management
Sensitivity and Specificity
Mass Screening
Enzyme-Linked Immunosorbent Assay
Hepatitis C
Reverse Transcriptase Polymerase Chain Reaction
Subject: Blood Transfusion
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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