|Title:||Development of the International Consortium for Blood Safety [ICBS] HCV panels|
El Nageh, M.M.
|Abstract:||To evaluate the sensitivity and specificity of assays used to screen blood for antibody to hepatitis C virus [HCV] infection, the International Consortium for Blood Safety [ICBS] established fully characterized ICBS panels. ICBS collected and characterized 1007 anti-HCV-positive plasma units from geographically diverse origins by ELISA, RIBA, RT-PCR, and sequence-based genotyping, 539 of which met the definition of a true positive. Of these, 200 confirmed positive plasma units, representing the 6 major HCV genotypes, were selected to assemble the true-positive constituents of the panel. The negative panel comprises 181 plasma units collected from the USA. The panels have proved valuable for determining the performance of anti-HCV assays thus permitting national authorities, especially in resource-limited countries, to make informed decisions on selection of affordable and reliable assays|
Sensitivity and Specificity
Enzyme-Linked Immunosorbent Assay
Reverse Transcriptase Polymerase Chain Reaction
|Appears in Collections:||EMRO Journal Articles (EMHJ)|
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