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Title: Assessment of the pharmaceutical quality of omeprazole capsule brands marketed in Egypt
Authors: El Sayed, A.
Boraie, N.A.
Ismail, F.A.
El Khordagui, L.K.
Khalil, S.A.
Issue Date: 2007
Language: English
Abstract: The pharmaceutical quality of 7 local omeprazole capsule brands in Egypt was assessed relative to the proprietary product [Losec[R]]. Drug content, content uniformity, drug release [using USP test for enteric coated articles and a modified release test] were determined. Products were subjected to a 3-month stability study. Of the 7 brands, 6 had satisfactory drug content and content uniformity. All brands passed the USP drug release test. The modified release test proved to be more discriminative. After 3 months storage, drug content of 3 brands remained > 90% and 2 of these brands maintained drug release above 75%. Changes in pellet appearance during storage were indicative of omeprazole chemical degradation
Description: 1427-1437
Keywords: Omeprazole
Anti-Ulcer Agents
Chemistry, Pharmaceutical
Drug Costs
Drug Stability
Drug Storage
Tablets, Enteric-Coated
Subject: Omeprazole
ISSN: 1020-3397
Other Identifiers:
Appears in Collections:EMRO Journal Articles (EMHJ)

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