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Title: Effect of methoxyverapamil, diltiazem, morphine and their combination on the formation of irreversibly sickled cells: an in vitro study
Authors: Ahmed, Jawad H.
Al Diwan, Manal S.
Jawad, Abdullah M.
Issue Date: 1997
Language: English
Abstract: The effect of methoxyverapamil and diltiazem [calcium antagonists] and morphine [calcium antagonist activity] on the formation of irreversibly sickled cells [ISCs] was investigated. Methoxyverapamil at therapeutic concentration and 10 times that level resulted in a 12% and 21% reduction in the formation of ISCs respectively, which was statistically significant. Diltiazem also produced a significant reduction in ISCs but morphine produced no significant reduction. Combination of these drugs produced a net effect similar to their individual effects. These drugs might be useful in decreasing the intensity of sickling crises and vaso-occlusive events. Thus in vivo trials in patients with sickle-cell disease are suggested
Description: 301-309
Keywords: Anemia, Sickle Cell
Gallopamil
Diltiazem
Morphine
Calcium
Calcium
Subject: Anemia, Sickle Cell
URI: http://www.who.int/iris/handle/10665/117373
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0302/emhj_1997_3_2_301_309.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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