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Title: Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients
Authors: Saleh, A.
Kamel, L.
Ghali, A.
Ismail, A.
El Khayat, H.
Issue Date: 2007
Language: English
Abstract: To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [HE]. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE
Description: 1114-1123
Keywords: Hepatic Encephalopathy
S100 Proteins
Sensitivity and Specificity
Early Detection
Phosphopyruvate Hydratase
Blood-Brain Barrier
Subject: Hepatic Encephalopathy
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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