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Title: Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test
Authors: El Beshlawy, A.
Kaddah, N.
Moustafa, A.
Mouktar, G.
Youssry, I.
Issue Date: 2007
Language: English
Abstract: To estimate beta-thalassaemia carrier rate and to determine an accurate mass screening test, we tested 1000 randomly selected children aged 5-16 years from different geographical areas of Egypt. Microcytosis was present in 412 participants. The osmotic fragility test was positive in 81.1% of the 90 beta-thalassaemia carriers; in the indeterminate group [12 participants], the test was positive in 83.3%; in the 310 who were iron deficient, the test was positive in 63.9%. beta-thalassaemia carrier rate was >/= 9%. Serum iron, microcytosis, HbA2 level and transferrin saturation were accurate tests for detecting carriers. For the one-tube osmotic fragility test, sensitivity was 87.0% and specificity 34.1%; the test has limited use for a mass screening programme in Egypt, where iron deficiency is prevalent
Description: 780-786
Keywords: Heterozygote Detection
Osmotic Fragility
Sensitivity and Specificity
Transferrin
Iron
Hemoglobin A2
Subject: beta-Thalassemia
URI: http://www.who.int/iris/handle/10665/117312
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1304/13_4_2007_780_786.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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