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Title: Parental consanguinity among parents of neonates with congenital hypothyroidism in Isfahan
Authors: Hashemipour, M.
Amini, M.
Talaie, M.
Kelishadi, R.
Hovespian, S.
Iranpour, R.
Salek, M.
Haghigh, S.
Khatibi, K.H.
Issue Date: 2007
Language: English
Abstract: We determined the prevalence of congenital hypothyroidism and the rate of consanguinity among parents of hypothyroid neonates among 93 381 neonates born in 17 hospitals in Isfahan from May 2002 to April 2005. Serum thyroxine [T4] and thyroid stimulating hormone [TSH] levels were measured on the 3rd-7th day of birth and neonates with abnormal levels were recalled and the levels reassessed. Those with TSH </= 10 mIU/L and T4 < 6.5 micro g/dL on the second assay were considered hypothyroid. In all, 1038 neonates were recalled and 274 were diagnosed as hypothyroid. There was a significant association between parental consanguinity and congenital hypothyroidism [P = 0.006]; congenital hypothyroidism was commoner in neonates with 1st cousin parental consanguinity than 2nd cousin parental consanguinity [P = 0.008]
Description: 567-574
Keywords: Consanguinity
Gene Frequency
Infant, Newborn
Subject: Congenital Hypothyroidism
URI: http://www.who.int/iris/handle/10665/117285
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1303/13_3_2007_567_574.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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