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Title: Relation between hypercholesterolaemia and vascular endothelial microinflammation
Authors: El Wakkad, A.S.
Mohamed, S.I.
Fathalla, M.
Issue Date: 2007
Language: English
Abstract: We investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 [IL-6] as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher [P < 0.001] in the study group and positively correlated with cholesterol [P < 0.001] and low-density lipoprotein [LDL] [P < 0.002]. Glutathione peroxidase activity was also significantly higher [P < 0.001] with positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Markers for endothelial cell function were significantly higher in the study group [P < 0.001] with a positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease
Description: 515-521
Keywords: Endothelium, Vascular
Vascular Diseases
Subject: Endothelium, Vascular
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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