Relation between hypercholesterolaemia and vascular endothelial microinflammation
AbstractWe investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 [IL-6] as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher [P < 0.001] in the study group and positively correlated with cholesterol [P < 0.001] and low-density lipoprotein [LDL] [P < 0.002]. Glutathione peroxidase activity was also significantly higher [P < 0.001] with positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Markers for endothelial cell function were significantly higher in the study group [P < 0.001] with a positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease
El Wakkad, A.S., Mohamed, S.I. & Fathalla, M. (2007). Relation between hypercholesterolaemia and vascular endothelial microinflammation. http://www.who.int/iris/handle/10665/117278
EMHJ - Eastern Mediterranean Health Journal, 13 (3), 515-521, 2007
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