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Title: Platelet storage time and cytokine [IL-2R, IL-8, TNF-alpha] levels
Authors: Bayraktarog lu, Z.
Yilmaz, N.
Cicek, H.K.
Karafak, A.
Gul, E.
Issue Date: 2007
Language: English
Abstract: This study investigated whether cytokine accumulation in plasma of platelet concentrates obtained from single apheresis donors was beyond the acceptable limits of white blood cell contamination at different storage time-points. Samples were obtained from 11 voluntary apheresis donors. All products were heavily contaminated with leukocytes. Sampling times from stored platelets were 0, 1, 3, 5 days respectively. Platelet, white blood cell counts and cytokines [IL-2R, IL-8 and TNF-alpha] were measured. The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels
Description: 79-84
Keywords: Leukocytes
Interleukin-8
Interleukin-2 Receptor alpha Submit
Cryopreservation
Leukocyte Count
Tumor Necrosis Factor-alpha
Subject: Plateletpheresis
URI: http://www.who.int/iris/handle/10665/117227
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1301/13_1_2007_79_84.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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