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Title: Efficacy of chloroquine and sulfadoxine/pyrimethamine mono-and combined therapy against falciparum malaria in Sudan
Authors: El Amin, S.B.
Malik, El F.M.
Ahmed, El D.S.
El Abadi, E.K.
Mohamad, T.A.
Issue Date: 2007
Language: English
Abstract: We assessed the efficacy of chloroquine and sulfadoxine/pyrimethamine monotherapy in several sentinel sites in northern Sudan and the efficacy of combined therapy in 2 sites. Chloroquine efficacy in children under 5 years was also assessed in 2 sites in southern Sudan. Patients with indications of uncomplicated falciparum malaria and sufficient parasite density were enrolled. The chloroquine failure rates in the northern and southern sites were 43.4% and 80.2% respectively. Treatment failure was significantly higher in children than adults, while there was no significant sex difference. Sulfadoxine/pyrimethamine had an overall failure rate of 4.4%. Combination of the 2 drugs had a failure rate of 14.5% and 5.9% in the 2 sites
Description: 25-34
Keywords: Chloroquine
Pyrimethamine
Sulfadoxine
Drug Therapy, Combination
Treatment Outcome
Subject: Malaria, Falciparum
URI: http://www.who.int/iris/handle/10665/117220
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1301/13_1_2007_25_34.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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