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Title: In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region
Authors: Saleh, S.M.A.
El Sissy, A.A.
Ismail, E.M.
Issue Date: 1997
Language: English
Abstract: Twenty cases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC
Description: 58-67
Keywords: Carcinoma, Basal Cell
Antibodies, Monoclonal
Subject: Head and Neck Neoplasms
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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