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Title: Coeliac disease in Sudanese children with clinical features suggestive of the disease
Authors: Mohammed, I.M.
Karrar, Z.E.A.
El Safi, S.H.
Issue Date: 2006
Language: English
Abstract: Our prospective hospital- based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high- risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months- 18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 [22.5%]. Antigliadin antibodies [AGA- IgG, AGA- IgA or both] were high in 44; endomysial antibody retest was high in 30. Guardians of 12 children refused consent for biopsy. The other 18 were biopsied: 5 had total villous atrophy, 8 subtotal and 5 partial. All improved with gluten- free diet. Degree of villous atrophy did not correlate with diarrhoea duration or severity, anaemia severity or serological titres
Description: 582-589
Keywords: Celiac Disease
Celiac Disease
Gliadin
Immunoglobulin A
Intestinal Mucosa
Subject: Celiac Disease
URI: http://www.who.int/iris/handle/10665/117122
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1205/12_5_2006_582_589.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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