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Methyl isobutyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by K. Chipman
Chipman, K; World Health Organization; International Programme on Chemical Safety ( 1990 )

Evalutes risks to human health and the environment posed by the widespread production and use of methyl isobutyl ketone as a solvent, with major applications in the production of lacquers and paint solvents, including car and industrial spray paints. Methyl isobutyl ketone also occurs naturally in food, is a permitted flavouring agent, and is used in food contact packaging materials. Sections concerned with the behaviour of methyl isobutyl ketone in the environment note its rapid evaporation into the atmosphere, rapid photo-transformation, ready biodegredation, and low potential for bioaccumulation. A review of data on metabolic pathways and toxicity to organisms concludes that production and use of this chemical pose no threat to wildlife or the environment, except in the case of accidental spills or inappropriate disposal of wastes. A review of studies conducted in human volunteers and in occupationally-exposed workers concludes that exposure to methyl isobutyl ketone can cause eye and respiratory irritation as well as symptoms of headache, nausea, and vertigo. The review found no evidence that exposure to this chemical causes permanent damage to the nervous system of workers or that its presence in the environment and in food poses any threat to the general population

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