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Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
ARSENIC
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General Information
CAS number:
7440-38-2
Functional Class:
Food Contaminant
METALS
Evaluations
Evaluation year
:
2010
Comments:
The inorganic arsenic lower limit on the benchmark dose for a 0.5% increased incidence of lung cancer (BMDL0.5) was determined from epidemiological studies to be 3.0 μg/kg bw per day (2–7 μg/kg bw per day based on the range of estimated total dietary exposure) using a range of assumptions to estimate total dietary exposure to inorganic arsenic from drinkingwater and food.
Tolerable Intake:
The provisional tolerable weekly intake (PTWI) of 15 μg/kg bw withdrawn.
Report:
TRS 959-JECFA 72
Tox Monograph:
FAS 63-JECFA 72
Previous Years:
1983, TRS 696-JECFA 27/29, FAS 18-JECFA 27/176. 0.002 (PMTDI)
1967, TRS 373/NMRS 43-JECFA 10/14. 0.05 (TENTATIVE MAXIMUM ACCEPTABLE DAILY LOAD). TE
1960, NMRS 29/TRS 220-JECFA 5/29
Evaluation year
:
1988
Tolerable Intake:
PTWI 0.015 mg/kg bw
Meeting:
33
Report:
TRS 776-JECFA 33/27
Tox Monograph:
FAS 24-JECFA 33/155
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