TARTRAZINE

Overview

Chemical Names
Trisodium 5-hydroxy-1-(4-sulfonatophenyl)-4-(4-sulfonatophenylazo)-h-pyrazol- 3-carboxylate
Synonyms
C.I.Food Yellow 4; FD and C Yellow No. 5
CAS number
1934-21-0
INS
102
Functional Class
Food Additives
COLOUR
INS matches
102

Evaluations

Evaluation year: 2016

ADI:
0–10 mg/kg bw

Comments:
JECFA established an ADI of 0–10 mg/kg bw, on the basis of a NOAEL of 984 mg/kg bw per day for reductions in body weight in a chronic rat study, with application of a 100-fold uncertainty factor to account for interspecies and intraspecies variability. JECFA withdrew the previous ADI of 0–7.5 mg/kg bw per day. JECFA noted that the dietary exposure estimate for children aged 1–10 years was below the upper bound of the ADI and concluded that dietary exposure to tartrazine for the general population, including children, does not present a health concern.
Meeting:
82
Specs Code:
R
Report: 
">TRS 1000-JECFA 82/63
Tox Monograph: 
FAS 73 JECFA 82/219
Specification: 
">FAO JECFA Monographs 19/112

Evaluation year: 1964

ADI:
0-7.5 mg/kg bw
Meeting:
08
Specs Code:
R (1984)
Report: 
NMRS 38/TRS 309-JECFA 8/14
Tox Monograph: 
FAS 66.25/NMRS 38B-JECFA 8/88
Specification: 
COMPENDIUM ADDENDUM 10/FNP 52 Add.10/34 (METALS LIMITS) (2002). R; FAO JECFA Monographs 1 vol.3/493
Previous Years:
1984, FNP 31/1-JECFA 28/133. R; COMPENDIUM/1481 1964, NMRS 38/TRS 309-JECFA 8/14, FAS 66.25/NMRS 38B-JECFA 8/88. 0-7.5. FU. R 1959, NMRS VOL. II-IV/95. N
1984, FNP 31/1-JECFA 28/133. R; COMPENDIUM/1481 1964, NMRS 38/TRS 309-JECFA 8/14, FAS 66.25/NMRS 38B-JECFA 8/88. 0-7.5. FU. R 1959, NMRS VOL. II-IV/95. N