BRILLIANT BLUE FCF

Overview

Chemical Names
disodium 3-[N-ethyl-N-[4-[[4-[N-ethyl-N- (3-sulfobenzyl)amino]phenyl](2-sulfophenyl)methylene]-2,5-cyclohexadiene-1-ylidene]ammoniomethyl]benzenesulfonate
Synonyms
C.I. FOOD BLUE 2; FD and C BLUE No. 1
CAS number
3844-45-9
INS
133
Functional Class
Food Additives
COLOUR
INS matches
133

Evaluations

Evaluation year: 2017

ADI:
0–6 mg/kg bw

Comments:
JECFA concluded that the available data support the revision of the ADI for Brilliant Blue FCF. In a long-term toxicity study in rats, a no-observed-adverse-effect level (NOAEL) of 631 mg/kg body weight (bw) per day was identified, based on a 15% decrease in mean terminal body weight and decreased survival of females at 1318 mg/kg bw per day. JECFA established an ADI of 0–6 mg/kg bw based on this NOAEL by applying an uncertainty factor of 100 for interspecies and intraspecies differences.
Meeting:
84
Specs Code:
R
Report: 
">TRS 1007-JECFA 84/9
Tox Monograph: 
FAS 75 JECFA 84/3
Specification: 
FAO JECFA Monographs 20/13

Evaluation year: 1969

ADI:
0-12.5 mg/kg bw
Meeting:
13
Specs Code:
R (1984)
Report: 
NMRS 46/TRS 445-JECFA 13/12
Tox Monograph: 
FAS 70.36/NMRS 46A-JECFA 13/24
Specification: 
COMPENDIUM ADDENDUM 10/FNP 52 Add.10/34 (METALS LIMITS) (2002); FAO JECFA Monographs 1 vol.1/165
Previous Years:
1984, FNP 31/1-JECFA 28/31. R; COMPENDIUM/217 1969, NMRS 46/TRS 445-JECFA 13/12, FAS 70.36/NMRS 46A-JECFA 13/24. 0-12.5. FU. S 1964, NMRS 38/TRS 309-JECFA 8/21, FAS 66.25/NMRS 38B-JECFA 8/27. NO ADI. NO. R 1959, NMRS VOL II-IV/107. N
1984, FNP 31/1-JECFA 28/31. R; COMPENDIUM/217 1969, NMRS 46/TRS 445-JECFA 13/12, FAS 70.36/NMRS 46A-JECFA 13/24. 0-12.5. FU. S 1964, NMRS 38/TRS 309-JECFA 8/21, FAS 66.25/NMRS 38B-JECFA 8/27. NO ADI. NO. R 1959, NMRS VOL II-IV/107. N