Pivotal Study: | Clinical trial in postmenopausal women (Moore et al., 1978): The effects of various dosages of orally administered conjugated
estrogens, mestranol, and ethinylestradiol on serum corticosteroid-binding globulin (CBG)-binding capacity was assessed in three healthy postmenopausal women, each of whom received Premarin(R) orally at 0.3, 0.62, 1.2, or 2.5 mg/day for 14 days. Each dose increased serum CBG-binding capacity, but the increase was not significant at 0.3 mg/day. |