Chapter II

Neoplasms
(C00-D48)

Neoplasms of uncertain or unknown behaviour
(D37-D48)


Note:	Categories D37-D48 classify by site neoplasms of uncertain or unknown behaviour, i.e., there is doubt whether the neoplasm is malignant or benign. Such neoplasms are assigned behaviour code /1 in the classification of the morphology of neoplasms.


D37	Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
D37.0	Lip, oral cavity and pharynx
	Aryepiglottic fold: · NOS · hypopharyngeal aspect · marginal zone Major and minor salivary glands Vermilion border of lip
	Excludes:	aryepiglottic fold, laryngeal aspect ( D38.0 ) epiglottis: · NOS ( D38.0 ) · suprahyoid portion ( D38.0 ) skin of lip ( D48.5 )
D37.1	Stomach
D37.2	Small intestine
D37.3	Appendix
D37.4	Colon
D37.5	Rectum
	Rectosigmoid junction
D37.6	Liver, gallbladder and bile ducts
	Ampulla of Vater
D37.7	Other digestive organs
	Anal: · canal · sphincter Anus NOS Intestine NOS Oesophagus Pancreas
	Excludes:	anal: · margin ( D48.5 ) · skin ( D48.5 ) perianal skin ( D48.5 )
D37.9	Digestive organ, unspecified


D38	Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
	Excludes:	heart ( D48.7 )
D38.0	Larynx
	Aryepiglottic fold, laryngeal aspect Epiglottis (suprahyoid portion)
	Excludes:	aryepiglottic fold: · NOS ( D37.0 ) · hypopharyngeal aspect ( D37.0 ) · marginal zone ( D37.0 )
D38.1	Trachea, bronchus and lung
D38.2	Pleura
D38.3	Mediastinum
D38.4	Thymus
D38.5	Other respiratory organs
	Accessory sinuses Cartilage of nose Middle ear Nasal cavities
	Excludes:	ear (external)(skin) ( D48.5 ) nose: · NOS ( D48.7 ) · skin ( D48.5 )
D38.6	Respiratory organ, unspecified


D39	Neoplasm of uncertain or unknown behaviour of female genital organs
D39.0	Uterus
D39.1	Ovary
D39.2	Placenta
	Chorioadenoma destruens Hydatidiform mole: · invasive · malignant
	Excludes:	hydatidiform mole NOS ( O01.9 )
D39.7	Other female genital organs
	Skin of female genital organs
D39.9	Female genital organ, unspecified


D40		Neoplasm of uncertain or unknown behaviour of male genital organs
D40.0		Prostate
D40.1		Testis
D40.7		Other male genital organs
		Skin of male genital organs
D40.9		Male genital organ, unspecified


D41	Neoplasm of uncertain or unknown behaviour of urinary organs
D41.0	Kidney
	Excludes:	renal pelvis ( D41.1 )
D41.1	Renal pelvis
D41.2	Ureter
D41.3	Urethra
D41.4	Bladder
D41.7	Other urinary organs
D41.9	Urinary organ, unspecified


D42		Neoplasm of uncertain or unknown behaviour of meninges
D42.0		Cerebral meninges
D42.1		Spinal meninges
D42.9		Meninges, unspecified


D43	Neoplasm of uncertain or unknown behaviour of brain and central nervous system
	Excludes:	peripheral nerves and autonomic nervous system ( D48.2 )
D43.0	Brain, supratentorial
	Cerebral ventricle Cerebrum
	Frontal Occipital Parietal Temporal		} } } }	lobe
	Excludes:	fourth ventricle ( D43.1 )
D43.1	Brain, infratentorial
	Brain stem Cerebellum Fourth ventricle
D43.2	Brain, unspecified
D43.3	Cranial nerves
D43.4	Spinal cord
D43.7	Other parts of central nervous system
D43.9	Central nervous system, unspecified
	Nervous system (central) NOS


D44	Neoplasm of uncertain or unknown behaviour of endocrine glands
	Excludes:	endocrine pancreas ( D37.7 ) ovary ( D39.1 ) testis ( D40.1 ) thymus ( D38.4 )
D44.0	Thyroid gland
D44.1	Adrenal gland
D44.2	Parathyroid gland
D44.3	Pituitary gland
D44.4	Craniopharyngeal duct
D44.5	Pineal gland
D44.6	Carotid body
D44.7	Aortic body and other paraganglia
D44.8	Pluriglandular involvement
	Multiple endocrine adenomatosis
D44.9	Endocrine gland, unspecified


D45		Polycythaemia vera
		Morphology code M9950 with behaviour code /1


D46	Myelodysplastic syndromes
	Includes:	morphology code M998 with behaviour code /1
D46.0	Refractory anaemia without sideroblasts, so stated
D46.1	Refractory anaemia with sideroblasts
D46.2	Refractory anaemia with excess of blasts
D46.3	Refractory anaemia with excess of blasts with transformation
D46.4	Refractory anaemia, unspecified
D46.7	Other myelodysplastic syndromes
D46.9	Myelodysplastic syndrome, unspecified
	Myelodysplasia NOS Preleukaemia (syndrome) NOS


D47	Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
	Includes:	morphology codes M974, M976, M996-M997 with behaviour code /1
D47.0	Histiocytic and mast cell tumours of uncertain and unknown behaviour
	Mast cell tumour NOS Mastocytoma NOS
	Excludes:	mastocytosis (cutaneous) ( Q82.2 )
D47.1	Chronic myeloproliferative disease
	Myelofibrosis (with myeloid metaplasia) Myeloproliferative disease, unspecified Myelosclerosis (megakaryocytic) with myeloid metaplasia
D47.2	Monoclonal gammopathy
D47.3	Essential (haemorrhagic) thrombocythaemia
	Idiopathic haemorrhagic thrombocythaemia
D47.7	Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
D47.9	Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
	Lymphoproliferative disease NOS


D48	Neoplasm of uncertain or unknown behaviour of other and unspecified sites
	Excludes:	neurofibromatosis (nonmalignant) ( Q85.0 )
D48.0	Bone and articular cartilage
	Excludes:	cartilage of: · ear ( D48.1 ) · larynx ( D38.0 ) · nose ( D38.5 ) connective tissue of eyelid ( D48.1 ) synovia ( D48.1 )
D48.1	Connective and other soft tissue
	Connective tissue of: · ear · eyelid
	Excludes:	cartilage (of): · articular ( D48.0 ) · larynx ( D38.0 ) · nose ( D38.5 ) connective tissue of breast ( D48.6 )
D48.2	Peripheral nerves and autonomic nervous system
	Excludes:	peripheral nerves of orbit ( D48.7 )
D48.3	Retroperitoneum
D48.4	Peritoneum
D48.5	Skin
	Anal: · margin · skin Perianal skin Skin of breast
	Excludes:	anus NOS ( D37.7 ) skin of genital organs ( D39.7 , D40.7 ) vermilion border of lip ( D37.0 )
D48.6	Breast
	Connective tissue of breast Cystosarcoma phyllodes
	Excludes:	skin of breast ( D48.5 )
D48.7	Other specified sites
	Eye Heart Peripheral nerves of orbit
	Excludes:	connective tissue ( D48.1 ) skin of eyelid ( D48.5 )
D48.9	Neoplasm of uncertain or unknown behaviour, unspecified
	"Growth" NOS Neoplasm NOS New growth NOS Tumour NOS

Processed on 29.10.2004 M.S.

Source: World Health Organization