Predictive Value of Rodent Forestomach and Gastric Neuroendocrine Tumours in Evaluating Carcinogenic Risks to Humans
Views and Expert Opinions of an IARC Working Group
IARC Technical Report, No 39
IARC
ISBN-13    9789283224211 ISBN-10    9283224213
Order Number    17700039   
Price    CHF    30.00 / US$    36.00 Developing countries:    CHF    21.00
English     2003        183   pages
Summary
Table of contents
Related Publications
Translation(s) available
 
 
 
 
Summary
This report of a workshop examines the mechanisms by which tumours of the forestomach and tumours of gastric neuroendocrine cell origin occur in rodents, and considers the predictive value of these tumours for the identification of carcinogenic hazards to humans. Etiological risk factors in rodents are summarized and evidence for the possible carcinogenic mechanisms involved is discussed. Recommendations are presented on how mechanistic data could be used in overall evaluations of carcinogenicity to humans. Summary reports at the beginning of each section use the background scientific reviews and case studies that were prepared before the workshop by individual participants. These individually authored papers formed the basis for the discussions that were held and are also included in this report.