Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis
IARC Scientific Publication, No 150
Singer, B., Bartsch, H.
IARC
ISBN-13    9789283221500 ISBN-10    9283221508
Order Number    17300150   
Price    CHF    55.00 / US$    66.00 Developing countries:    CHF    38.50
English     1999        377   pages
Summary
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Summary
The use of exocyclic adducts as biomarkers offers a promising tool in studies of cancer etiology and prevention, particularly for human neoplasias in which the causative factors and mechanisms are still poorly understood. Presentations at an international conference which resulted in this volume comprise a comprehensive treatise on the current state of the art and scientific information on exocyclic DNA adducts. The volume includes sections on ultrasensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, use as biomarkers and their role in mutagenesis and carcinogenesis.