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| Summary |
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This eighty-ninth volume of the IARC Monographs is the third and last of a series on
tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and
involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC,
2004a). Volume 85 summarized the evidence on the carcinogenic risk of chewing betel quid
with and without tobacco (IARC, 2004b). That volume explored the variety of products
chewed in South Asia and other parts of the word that contain areca nut in combination with
other ingredients, often including tobacco. In this eighty-ninth volume, the carcinogenic
risks associated with the use of smokeless tobacco, including chewing tobacco and snuff, are
considered in a first monograph. The second monograph reviews some tobacco-specific
nitrosamines. These agents were evaluated earlier in Volume 37 of the Monographs (IARC,
1985), and information gathered since that time has been summarized and evaluated.
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