WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fourth Edition
WHO Classification of Tumours, Volume 2
IARC WHO Classification of Tumours, No 2
Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Vardiman, J.W
ISBN-13    9789283224310 ISBN-10    9283224310
Order Number    17004002 Format    Paper Back
Price    CHF    122.00 / US$    146.40 Developing countries:    CHF    85.40
English     2008        439   pages
Table of contents
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Table of contents
WHO Classification
Summary table
Introduction to the classification of tumours of haematopoietic and lymphoid tissues

1 Introduction and overview of the classification of the myeloid neoplasms

2 Myeloproliferative neoplasms
Chronic myelogenous leukaemia, BCR-ABL1 positive
Chronic neutrophilic leukaemia
Polycythaemia vera
Primary myelofibrosis
Essential thrombocythaemia
Chronic eosinophilic leukaemia, NOS
Cutaneous mastocytosis
Systemic mastocytosis
Mast cell leukaemia
Mast cell sarcoma
Extracutaneous mastocytoma
Myeloproliferative neoplasm, unclassifiable

3 Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA,PDGFRB or FGFR1

4 Myelodysplastic/myeloproliferative neoplasms
Chronic myelomonocytic leukaemia
Atypical chronic myeloid leukaemia, BCR-ABL1 negative
Juvenile myelomonocytic leukaemia
Myelodysplastic/myeloproliferative neoplasm, unclassifiable

5 Myelodysplastic syndromes
Myelodysplastic syndromes/neoplasms, overview
Refractory cytopenia with unilineage dysplasia
Refractory anaemia with ring sideroblasts
Refractory cytopenia with multilineage dysplasia
Refractory anaemia with excess blasts
Myelodysplastic syndrome with isolated del(5q)
Myelodysplastic syndrome, unclassifiable
Childhood myelodysplastic syndrome
Refractory cytopenia of childhood
v 6 Acute myeloid leukaemia (AML) and related precursor neoplasms
AML with recurrent genetic abnormalities
AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
Acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-RARA
AML with t(9;11)(p22;q23); MLLT3-MLL
AML with t(6;9)(p23;q34); DEK-NUP214v AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2);RPN1-EVI1
AML (megakaryoblastic) with t(1;22)(p13;q13);RBM15-MKL1
AML with mutated NPM1
AMLwith mutated CEBPA
AML with myelodysplasia-related changes
Therapy-related myeloid neoplasms
Acute myeloid leukaemia, NOS
AML with minimal differentiation
AML without maturation
AML with maturation
Acute myelomonocytic leukaemia
Acute monoblastic and monocytic leukaemia
Acute erythroid leukaemia
Acute megakaryoblastic leukaemia
Acute basophilic leukaemia
Acute panmyelosis with myelofibrosis
Myeloid sarcoma
Myeloid proliferations related to Down syndrome
Transient abnormal myelopoiesis
Myeloid leukaemia associated with Down syndrome
Blastic plasmacytoid dendritic cell neoplasm

7 Acute leukaemias of ambiguous lineage
Acute undifferentiated leukaemia
Mixed phenotype acute leukaemia with t(9;22)(q34;q11.2); BCR-ABL1
Mixed phenotype acute leukaemia with t(v;11q23); MLL rearranged
Mixed phenotype acute leukaemia, B/myeloid, NOS 152
Mixed phenotype acute leukaemia, T/myeloid, NOS 153
Mixed phenotype acute leukaemia, NOS - rare types
Other ambiguous lineage leukaemias
Natural killer (NK)-cell lymphoblastic leukaemia/lymphoma

8 Introduction and overview of the classification of the lymphoid neoplasms
9 Precursor lymphoid neoplasms
B lymphoblastic leukaemia/lymphoma, NOS
B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities
B lymphoblastic leukaemia/lymphoma with t(9:22)(q34;q11.2); BCR-ABL1
B lymphoblastic leukaemia/lymphoma with t(v;11q23); MLL rearranged
B lymphoblastic leukaemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)
B lymphoblastic leukaemia/lymphoma with hyperdiploidy
B lymphoblastic leukaemia/lymphoma with hypodiploidy (Hypodiploid ALL)
B lymphoblastic leukaemia/lymphoma with t(5;14)(q31;q32); IL3-IGH
B lymphoblastic leukaemia/lymphoma with t(1;19) (q23;p13.3); E2A-PBX1(TCF3-PBX1)
T lymphoblastic leukaemia/lymphoma

10 Mature B-cell neoplasms
Chronic lymphocytic leukaemia /small lymphocytic lymphoma
B-cell prolymphocytic leukaemia
Splenic marginal zone lymphoma
Hairy cell leukaemia
Splenic B-cell lymphoma/leukaemia, unclassifiable
Splenic diffuse red pulp small B-cell lymphoma
Hairy cell leukaemia-variant
Lymphoplasmacytic lymphoma
Heavy chain diseases
Gamma heavy chain disease
Mu heavy chain disease
Alpha heavy chain disease
Plasma cell neoplasms
Monoclonal gammopathy of undetermined significance (MGUS)
Plasma cell myeloma
Solitary plasmacytoma of bone
Extraosseous plasmacytoma
Monoclonal immunoglobulin deposition diseases
Extranodal marginal zone lymphoma of mucosa- associated lymphoid tissue (MALT lymphoma)
Nodal marginal zone lymphoma
Follicular lymphoma
Primary cutaneous follicle centre lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), NOS
T cell/histiocyte-rich large B-cell lymphoma
Primary DLBCL of the CNS
Primary cutaneous DLBCL, leg type
EBV positive DLBCL of the elderly
DLBCL associated with chronic inflammation
Lymphomatoid granulomatosis
Primary mediastinal (thymic) large B-cell lymphoma
Intravascular large B-cell lymphoma
ALK positive large B-cell lymphoma
Plasmablastic lymphoma
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
Primary effusion lymphoma
Burkitt lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

11 Mature T- and NK-cell neoplasms
T-cell prolymphocytic leukaemia
T-cell large granular lymphocytic leukaemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK cell leukaemia
Epstein-Barr virus (EBV) positive T-cell lymphoproliferative diseases of childhood
Systemic EBV+ T-cell lymphoproliferative disease of childhood
Hydroa vacciniforme-like lymphoma
Adult T-cell leukaemia/lymphoma
Extranodal NK/T-cell lymphoma, nasal type
Enteropathy-associated T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
SÚzary syndrome
Primary cutaneous CD30 positive T-cell lymphoproliferative disorders
Primary cutaneous peripheral T-cell lymphomas, rare subtypes
Primary cutaneous gamma-delta T-cell lymphoma
Primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma
Primary cutaneous CD4 positive small/medium T-cell lymphoma
Peripheral T-cell lymphoma, NOS
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, ALK positive
Anaplastic large cell lymphoma, ALK negative

12 Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Classical Hodgkin lymphoma, introduction
Nodular sclerosis classical Hodgkin lymphoma
Mixed cellularity classical Hodgkin lymphoma
Lymphocyte-rich classical Hodgkin lymphoma
Lymphocyte-depleted classical Hodgkin lymphoma

13 Immunodeficiency-associated lymphoproliferative disorders
Lymphoproliferative diseases associated with primary immune disorders
Lymphomas associated with HIV infection
Post-transplant lymphoproliferative disorders (PTLD)
Plasmacytic hyperplasia and infectious- mononucleosis-like PTLD
Polymorphic PTLD
Monomorphic PTLD
Classical Hodgkin lymphoma type PTLD
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders

14 Histiocytic and dendritic cell neoplasms
Histiocytic sarcoma
Tumours derived from Langerhans cells
Langerhans cell histiocytosis
Langerhans cell sarcoma
Interdigitating dendritic cell sarcoma
Follicular dendritic cell sarcoma
Other rare dendritic cell tumours
Disseminated juvenile xanthogranuloma
Clinical advisory committee
Source of charts and photographs
Subject index