Chemical-specific Adjustment Factors for Interspecies Differences and Human Variability: Guidance Document for Use of Data in Dose/Concentration-response Asses.
IPCS Harmonization Project Document No.2
Nonserial Publication
World Health Organization
ISBN-13    9789241546782 ISBN-10    9241546786
Order Number    11500641 Format    Paper Back
Price    CHF    40.00 / US$    48.00 Developing countries:    CHF    28.00
English     2005        100   pages
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Summary
The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Programme on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix, and a glossary of terms is also provided.