Evaluation of Certain veterinary Drug Residues in Food
Fifty-second Report of the Joint FAO/WHO Expert Committee on Food Additives
Technical Report Series, No 893
World Health Organization
ISBN-13    9789241208932 ISBN-10    9241208937
Order Number    11000893 Format    E-book collection (PDF)
Price    CHF    20.00 / US$    24.00 Developing countries:    CHF    14.00
English     2000        110   pages
Summary
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Summary
Presents the conclusions of an expert committee commissioned to evaluate the safety of residues of selected veterinary drugs used in food-producing animals, to establish acceptable daily intakes for humans, and to recommend maximum residue limits. The report has two parts. Methodological issues are considered in the first part. For veterinary antimicrobial drugs, the report sets out data requirements for the systematic safety evaluation of residues in view of various concerns related to their effects on the human intestinal microflora. The report introduces a comprehensive decision-tree for determining the potential adverse effects of residues of antimicrobial drugs that takes account of all relevant microbiological data from model in vitro and in vivo test systems. Other issues discussed include procedures for assessing the safety of residues at the injection site, procedures for establishing maximum residue levels in several special cases, and statistical approaches for recommending maximum residue levels.
The main part of the report provides succinct summaries of the toxicological and residue data considered when evaluating substances under review, identifying any potential hazards to consumer health, and allocating an acceptable daily intake and maximum residue limits. Veterinary drugs considered include one b-adrenoceptor-blocking agent (carazolol), one anthelminthic agent (doramectin), four antimicrobial agents (dihydrostreptomycin, streptomycin, neomycin and thiamphenicol), two insecticides (deltamethrin and phoxim), four production aids (estradiol-17b, progesterone, testosterone and porcine somatotropins), and one tranquillizing agent (azaperone).
Evaluation of Certain Veterinary Drug Residues in Food
Fifty-fourth Report of the Joint FAO/WHO Expert Committee on Food Additives


Technical Report Series,
No. 900
2001, vi + 96 pages (available in English; French and Spanish in preparation)