WHO Expert Committee on the Evaluation of Certain Food Additives and Contaminants
Forty-sixth Report of the Joint FAO/WHO Expert Committee on Food Additives
Technical Report Series, No 868
World Health Organization
ISBN-13    9789241208680 ISBN-10    9241208686
Order Number    11000868 Format    E-book collection (PDF)
Price    CHF    14.00 / US$    16.80 Developing countries:    CHF    9.80
English     1997        77   pages
Table of contents
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Presents the conclusions of an expert committee commissioned to evaluate the safety for human consumption of selected food additives and contaminants and to establish acceptable daily intakes for these substances. The report has two parts. The first provides a general discussion of principles governing the toxicological evaluation of food additives and contaminants and the establishment and revision of specifications. Of particular importance is a description of a procedure for the safety evaluation of flavouring agents, which integrates data on intake, in relation to human intake thresholds, with information on structure-activity relationships, metabolism, and toxicity. The discussion also considers the toxicological significance of proliferative lesions of the adrenal medulla in rats fed polyols and other poorly digestible carbohydrates, concluding that the occurrence of these lesions is a species-specific phenomenon and is not relevant to the toxicological evaluation of these substances for humans.
The most extensive part provides succinct summaries of the toxicological data examined and factors considered when evaluating selected substances and allocating an acceptable daily intake. Evaluations are presented for one group of antioxidants (dodecyl, octyl and propyl gallate), one emulsifier (glycerol ester of wood rosin), three groups of flavouring agents (15 ethyl esters, isoamyl alcohol and 10 of its related esters, and 21 allyl esters), one sweetening agent (alitame), and one thickening agent (konjac flour). Miscellaneous substances evaluated include benzyl acetate, benzyl alcohol, benzaldehyde, benzoic acid and the benzoate salts, and sucrose acetate isobutyrate. A final evaluation addresses the risks posed by the contaminants, aflatoxins, giving particular attention to their potential carcinogenicity in different human populations. In view of weaknesses in the available data, no conclusions could be reached