Cardiovascular Disease Risk Factors: New Areas for Research
Report of a WHO Scientific Group
Technical Report Series, No 841
World Health Organization
ISBN-13    9789241208413 ISBN-10    9241208414
Order Number    11000841 Format    E-book collection (PDF)
Price    CHF    10.00 / US$    12.00 Developing countries:    CHF    7.00
English     1994        59   pages
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Summary
Identifies and assesses specific research areas where further investigation promises to yield better knowledge about the risk factors for cardiovascular disease and the most effective strategies for prevention. Addressed to scientists and research administrators, the report concentrates on new strategies for studying a number of established or suspected risks in order to clarify their significance as predictors of disease or factors causally linked to pathogenic mechanisms. The "classical" risk factors, such as high serum cholesterol levels, hypertension, and smoking, are not considered.
The report identifies ten promising new areas for further study. For each, a review of the scientific background is followed by a discussion of implications for prevention and control and precise recommendations for further research. These areas include nutritional factors, such as plant foods and antioxidants, and metabolic factors, including the possible roles of newly identified lipoprotein phenotypes, insulin resistance, and high levels of plasma homocysteine. Haemostatic factors are also considered, with particular attention given to the roles of fibrinogen, coagulation factor VII, platelet number, and fibrinolytic modulators. Other areas include the possible protective roles of alcohol, and especially of wine, and of physical activity.
Special attention is given to the need to study how hormone replacement therapy affects cardiovascular disease in women and to balance its potential benefits against the possible risks of endometrial and breast cancer. Other areas covered include the roles of genetic factors and of social, cultural and psychosocial factors that might explain the marked differences in mortality observed in different groups both within and between countries.