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| Relevance of N-Nitroso Compounds to Human Cancer (The): Exposures and Mechanisms |
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| IARC Scientific Publication No 84 |
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| IARC |
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ISBN-13
9789283211846
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ISBN-10
9283211847
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Order Number
17300084
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Price
CHF
11.12
/
US$
13.34
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Developing countries:
CHF
7.78
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English
1987
663
pages
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| Summary |
N-Nitroso compounds continue to serve as valuable tools in cancer research, not least in reflecting a complex system of formation and metabolism that is consistent with the multifactorial causes of non-occupational, as well as occupational cancers.
This volume is the proceedings of a IARC convened meeting on N-Nitroso Compounds. Many of the contributions reflect recent interest in endogenous formation of these compounds in humans and the need both to elucidate the microbiological and dietary conditions that affect this source of exposure and to establish a link with DNA damage and increased cancer incidence. In several studies, the potential connection between oral cancer and N-nitroso compounds in chewing tobacco was investigated further. The carcinogenicity of N-nitroso compounds in all of the 40 animal species so far tested and their ubiquitous occurrence support the hypothesis, which must now be tested, that they may have an etiological role in several other human cancers, such as those of the oesophagus, stomach, urinary bladder, pancreas and brain. |
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